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apalutamide will decrease the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications which can be CYP3A4 substrates may end up in reduced publicity to these medications.nelfinavir will boost the degree